Shri Mata Vaishno Devi University
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Associate Professor, School of Biotechnology
Shri Mata Vaishno Devi University, Katra, Jammu (January 2025–Present)
Assistant Professor, Amity Institute of Biotechnology & Amity Institute of Integrative Science and Health
Amity University Haryana, Gurugram (February 2016- June 2022)
Lecturer, Department of Microbiology,
Chaudhary Charan Singh University (November 2006–May 2010)
Head, Amity Institute of Integrative Science and Health, – Amity University Haryana (July 2023–January 2025)
Co-ordinator, M.Sc/PGD Data Science – Amity Institute of Integrative Science and Health, Amity University Haryana (February 2022–January 2025)
| Engineered nanomicelles inhibit the tumour progression via abrogating the prostaglandin-mediated immunosuppression, Poonam Yadav, Kajal Rana, Viviani Nardini, Ali Khan, Trishna Pani, Animesh Kar, Dolly Jain, Ruchira Chakraborty, Ragini Singh, Somesh K. Jha, Devashish Mehta, Harsh Sharma, Ravi Datta Sharma, S.V.S. Deo, Sagar Sengupta, Veena S. Patil, Lúcia Helena Faccioli, Ujjaini Dasgupta, Avinash Bajaj, Journal of Controlled Release 368 (2024) 548–565 DOI: https://doi.org/10.1016/j.jconrel.2024.03.009 |
| A Localized Hydrogel-mediated Chemotherapy Causes Immunogenic Cell Death via Activation of Ceramide-mediated Unfolded Protein Response, Animesh Kar, Dolly Jain, Sandeep Kumar, Kajal Rajput, Sanjay Pal,Kajal Rana,Raunak Kar,Somesh K. Jha, Nihal Medatwal, Prabhu Srinivas Yavvari, Nishant Pandey, Devashish Mehta, Harsh Sharma, Debanjan Bhattacharya, Manas K. Pradhan, Ravi Datta Sharma,Aasheesh Srivastava, Usha Agarwal, Arnab Mukhopadhyay, Sagar Sengupta,Veena S. Patil,Avinash Bajaj and Ujjaini Dasgupta, Sci. Adv.9,eadf2746(2023).DOI:10.1126/sciadv.adf2746 |
| Prediction of transcript structure and concentration using RNA-Seq data, Harsh Sharma, Trishna Pani, Ujjaini Dasgupta, Jyotsna Batra, Ravi Datta Sharma, Briefings in Bioinformatics, 2023, 1–9, DOI: https://doi.org/10.1093/bib/bbad022 IF-13.99 |
| Directed Evolution Detects Supernumerary Centric Chromosomes Conferring Resistance to Azoles in Candida auris, Aswathy Narayanan,Praveen Kumar,Anshu Chauhan,Mohit Kumar,Kusum Yadav,Atanu Banerjee,Ravi Datta Sharma,Shivaprakash M. Rudramurthy,Arunaloke Chakrabarti,Kaustuv Sanyal, Rajendra Prasad, mBio. 2022 Nov 29;13(6):e0305222 |
| Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors, Moumita Sarkar, Harsh Sharma, Parminder Singh, Ranbala Ranu, Ravi Datta Sharma, Usha Agrawal, Rahul Pal, iScience, 25 (7),104527,2022 IF-5.7 |
| Identification of Candidate mRNA Isoforms for Prostate Cancer-Risk SNPs Utilizing Iso-eQTL and sQTL Methods, Afshin Moradi, Harsh Sharma, Ravi Datta Sharma, Achala Fernando, Roberto A. Barrero and Jyotsna Batra, Int. J. Mol.Sci.2022,23,12406.IF-6.2 |
| Computational insights of the unfolding of N-Terminal domain of TDP-43 reveal the conformational heterogeneity in the unfolding pathway, Ruhar Singh, Tara Kashav, Ravi Datta Sharma, Andrew M. Lynn, Rajendra Prasad, Amresh Prakash, Vijay Kumar, Front. Mol. Neurosci. 15:822863,IF-5.13, doi: 10.3389/fnmol.2022.822863 |
| Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype, Trishna Pani, Kajal Rajput, Animesh Kar, Harsh Sharma, Rituparna Basak, Nihal Medatwal, Sandhini Saha, Gagan Dev, Sharwan Kumar, Siddhi Gupta, Arnab Mukhopadhyay, Dipankar Malakar, Tushar Maiti, Aneeshkumar G. Arimbasseri, SVS Deo, Ravi Sharma, Avinash Bajaj, and Ujjaini Dasgupta, Cell Death & Disease,12, Article number: 171 (2021),IF-8.4 |
| Intron distribution and emerging role of alternative splicing in fungi Suraya Muzafar, Ravi Datta Sharma, Neeraj Chauhan, Rajendra Prasad,FEMS Microbiology Letters, Volume 368, Issue 19, October 2021, fnab135, https://doi.org/10.1093/femsle/fnab135 |
| Microscopic and transcriptomic analyses of Dalbergoid legume peanut reveal a divergent evolution leading to Nod Factor dependent epidermal crack-entry and terminal bacteroid differentiation, Bikash Raul, Oindrila Bhattacharjee, Amit Ghosh, Priya Upadhyay, Kunal Tembhare, Ajeet Singh, Tarannum Shaheen, Asim Kumar Ghosh, Ivone Torres-Jerez, Nick Krom Josh Clevenger, Michael Udvardi, Brian E Scheffler, Peggy Ozias Akins, Ravi Dutta Sharma, Kaustav Bandyopadhyay, Vineet Gaur, Shailesh Kumar, Senjuti Sinharoy, Mol Plant Microbe Interact.,2021 Oct 23. doi: 10.1094/MPMI-05-21-0122-R |
| Identification of Nafamostat and VR23 as COVID-19 drug candidates by targeting 3CLpro and PLpro,Deep Bhowmik, Ravi D.Sharma, Amresh Prakash, Diwakar Kumara, Journal of Molecular Structure, 1233(2021),130094, IF-2.0 |
| A Novel Multi Class Random Forest (MCRF) Model for Detecting Small Peptides, Ankita Tripathi, Tapas Goswami,Shrawan Kumar Trivedi, Ravi Datta Sharma, International Journal of Information Management Data Insights, 1(2), November 2021, 100029 |
| Identifying the natural polyphenol Catechin as a multitargated agent against SARS-cvV2 For the plausible therapy of COVID19: An Integrated computational approach, Chandra Bhushan Mishra, Preeti Pandey, Ravi Datta Sharma, Md. Zubbair Malik, Raj Kumar, Mongre, Andrew. M. Lynn, Rajendra Prasad, Raok Jeon and Amresh Prakash, Briefings in Bioinformatics, (2020)Dec 31;bbaa378. doi: 10.1093/bib/bbaa378,Impact factor-11.6 |
| Identification of Best Features of Small Peptides Using Various Feature Selection, Ankita Tripathi, Tapas Goswami, Shrawan Kumar Trivedi and Ravi Datta Sharma, International Journal of Advanced Research in Engineering and Technology,11(12), 2020, pp. 384-394 |
| Bile Acid-tethered Docetaxel-based Nanomicelle Mitigates Tumor progression via Epigenetic Changes, Vedagopuram Sreekanth, Animesh Kar, Sandeep Kumar, Sanjay Pal, Poonam Yadav, Yamini Sharma, Varsha Komalla, Harsh Sharma, Radhey Shyam, Ravi D Sharma, Arnab Mukhopadhyay, Sagar Sengupta, Ujjaini Dasgupta, Avinash Bajaj, Angewandte Chemie,2020 Nov 30, Impact factor-15.3, DOI:10.1002/anie.202015173 |
| Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells, Julie Pratibha Singh, Manisha Dagar, Gunjan Dagar,Sudhir Rawal,Ravi Datta Sharma, Rakesh Kumar Tyagi,Sudhir Kumar,Gargi Bagchi, Plos One, 2020,15(9): e0226056 (IF-2.7) |
| Identification of Genome-Wide Alternative Splicing Events in Sequential, Isogenic Clinical Isolates of Candida albicans Reveals a Novel Mechanism of Drug Resistance and Tolerance to Cellular Stresses” by Suraya Muzafar, Ravi Sharma, Abdul Shah, Naseem Gaur, Ujjaini Dasgupta, Neeraj Chauhan, and Rajendra Prasad, MSphere, July 2020,5:e00608-20 (IF-4.2) |
| VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response, Sakshi Agarwal, Arun Sharma, Rania Bouzeyen, Amar Deep, Harsh Sharma, Kiran K Mangalaparthi, Keshava K Datta, Saqib Kidwai, Harsha Gowda, Raghavan Varadarajan, Ravi Datta Sharma, Krishan Gopal Thakur and Ramandeep Singh, Science Advances,03 Jun 2020:6(23),eaba6944 DOI: 10.1126/sciadv.aba6944,Impact factor-14.1 |
| A Localized Chimeric Hydrogel Therapy Combats Tumor Progression through Alteration of Sphingolipid Metabolism, Sanjay Pal, Nihal Medatwal, Sandeep Kumar, Animesh Kar,Varsha Komalla,Prabhu Srinivas Yavvari, Deepakkumar Mishra, Zaigham Abbas Rizvi,Shiv Nandan,Dipankar Malakar,Manoj Pillai,Amit Awasthi, Prasenjit Das,Ravi Datta Sharma,Aasheesh Srivastava,Sagar Sengupta, Ujjaini Dasgupta, and Avinash Bajaj, ACS Central Sciences,2019, 5 (10), 1648-1662, DOI:10.1021/acscentsci.9b00551,If-14.5 |
| Delineating the conformational dynamics of intermediate structures on the unfolding pathway of β-lactoglobulin in aqueous urea and dimethyl sulfoxide, Ruhar Singh, Naveen Kumar Meena, Trishala Das, Ravi Datta Sharma, Amresh Prakash Icon & Andrew M. Lynn, Journal of Biomolecular Structure and Dynamics,2020,Oct;38(17):5027-5036.DOI:10.1080/07391102.2019.1695669, IF-3.3 |
| Multiple transcription factors co-regulate the Mycobacterium tuberculosis adaptation, response to Vitamin C, Malobi Nandi, Kriti Sikri, Neha Chaudhary, Shekhar Chintamani Mande, Ravi Datta Sharma & Jaya Sivaswami Tyagi, BMC Genomics 20, Article number: 887(2019),Doi: 10.1186/s12864-019-6190-3 ,Impact factor-3.7 |
| Aberrant splicing of BAF45d in gliomas: a link between splicing regulation and transcription, Guillermo Aldave, Marisol Gonzalez-Huarriz,Angel Rubio, Juan Pablo Romero, Datta Ravi, Belén Miñana, Mar Cuadrado-Tejedor, Ana García- Osta, Roeland Verhaak, Enric Xipell, Naiara Martinez-Vélez, Arlet Acanda de la Rocha, Montserrat Puigdelloses, Marc García-Moure, Miguel Marigil, Jaime Gállego Pérez-Larraya, Oskar Marín-Bejar, Maite Huarte, Maria Stella Carro, Roberto Ferrarese, Cristobal Belda-Iniesta, Angel Ayuso,Ricardo Prat-Acín,Fernando Pastor, Ricardo Díez- Valle, Sonia Tejada, and Marta M. Alonso, Neuro-Oncology (2018),Volume 20, Issue 7, July 2018, Pages 930–941, DOI:10.1093/neuonc/noy007, Impact factor-12.3 |
| Identification of Plant Species using Supervised Machine Learning, Ankita Tripathi, Ravi Datta Sharma, Shrawan Kumar Trivedi, International Journal of Computer Applications 2018 (0975 – 8887), Volume 182 – No. 13, Impact factor-0.7 |
| Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity,Syed Tabrez, Ravi Sharma, Vaibhav Jain, Atif Siddiqui, and Arnab Mukhopadhyay, Nature Communications 8, Article number: 306 (2017), DOI:10.1038/s41467-017-00370-5, IF-15 |
| Understanding the molecular basis of stability in Kunitz (STI) family of inhibitors in terms of a conserved core tryptophan residue: A theoretical investigation, Ravi Datta Sharma, Nabajyoti Goswami, Debasree Ghosh, Sudip Majumder, Journal of Molecular Graphics and Modelling, 75(2017): 233-240, Impact factor-1.8 |
| RDM16 and STA1 regulate differential usage of exon/intron in RNA directed DNA Methylation pathway,Ravi Datta Sharma, Bert Bogaerts, Neha Goyal,Gene 2017 April 20(609): 62-67,DOI:10.1016/j.gene.2017.01.027,Impact factor-3.6 |
| A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer, Fernando J de Miguel, Ravi D Sharma et al., Molecular Oncology, 2016,Nov;10(9):1437-1449. DOI:10.1016/j.molonc.2016.08.001,Impact factor-6.6, ISSN: 1574-7891 |
| Data on RDM16 and STA1 regulate differential usage of exon/intron in RNA directed DNA Methylation pathway, Ravi Datta Sharma, Bert Bogaerts, Neha Goyal, Data in Brief 12 (2017) 261–268 |
| Identification of alternative splicing events regulated by the oncogenic factor SRSF1 in lung cancer, Fernando J de Miguel*, Ravi D Sharma*, María J Pajares, Luis M Montuenga, Angel Rubio, Ruben Pio, Cancer Res (2014)74:1105-1115,Impact factor-12.7,PMID: 24371231 *Joint First Authors |
| High Temperature Unfolding of a truncated hemoglobin by Molecular Dynamics Simulation, Ravi Datta Sharma, Rajnee Kanwal, Andrew M Lynn, Prerna Singh, Syed Tazeen Pasha, Tasneem Fatma, Safdar Jawaid, J Mol Model (2013)19:3993–4002.Imapct factor- 1.9 [PMID:23839248] |
| High temperature unfolding of Bacillus anthracis amidase-03 by molecular dynamics simulations, RD Sharma, AM Lynn, PK Sharma, Rajnee, Safdar jawaid, Bioinformation 3(10): 430-434 (2009). [PMID: 19759865] |
| A modelled structure for amidase-03 from Bacillus anthracis, RD Sharma, Nabajyoti Goswami, AM Lynn, Rajnee, PK Sharma, Safdar jawaid. Bioinformation 4(6):242-244 (2009). [PMID: 20975917] |
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Alternative splicing in glioblastoma: a big new world ahead,Marisol Gonzalez-Huarriz, Guillermo Aldave, Datta Ravi, Angel Rubio, Miguel Marigil, Patricia Jauregi, Ricardo Diez-Valle, Beatriz Vera, Arlet-Acanda de la Rocha, Sonia Tejada, Marta M. Alonso, In -4th Quadrennial Meeting of the World Federation of Neuro-Oncology and 2013 Scientific Meeting, San-Francisco. Neuro-Oncology, 15:iii12–iii31, 2013 DOI:10.1093/neuonc/not174 |
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Abstract 2124: Analysis of the functional relevance of novel alternative splicing events in non-small cell lung cancer, Fernando J. de Miguel, Ravi D. Sharma et al., Cancer res., August 1, 2015 -75;2124, doi:10.1158/1538-7445.AM2015-2124 |
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Chapter 2: Role of alternative splicing in health and diseases,Harsh Sharma, Kusum Yadav, Ravi Datta Sharma,Book:Transcription and Translation in Health and Disease,Editor(s): Manoj Garg, Gautam Sethi, Amit Kumar Pandey, Academic Press, 2023, Pages 19-36,ISBN 9780323995214, https://doi.org/10.1016/B978-0-323-99521-4.00002-7. |
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Chapter 34: In Silico Analysis of Endosymbionts of Bemisia tabaci (White Fly) by Artemis and Artemis Comparison Tool, Pardeep Kumar, Ravi Datta Sharma and Machiavelli Singh, Book: “Trends in Technology for Agriculture, Food, Environment and Health” Editors: R. K. Behl, Machiavelli Singh, Achim Ibenthal and Manfred J Kern released with AGROBIOS (INTERNATIONAL) ISBN: 978-81-947480-7-7 |
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Chapter 13: Solving the Structure of Amidase-03, Ravi Datta Sharma and Garima Bhardwaj,Book: “Microbial Catalysts. Volume “, Editors: SMA aziz, N Garg ,A aeron, CK Jha, SC Nayak, VK Bajpai released with NOVA Publisher (2019), ISBN: 978-1-53614-679-0 |
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PhD Thesis: Statistical analysis of expression data generated through RNA-Sequencing, by Ms Harsh Sharma to Amity University Haryana, Gurugram submitted on 03-08-2022 Awarded 03-02-2023,Supervisor -Dr.Ravi Datta Sharma, Co -Supervisor Dr. Jyotsana Batra, Shodhganga Link |
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PhD Thesis: Functional relationship between genetic variations and alternative splicing in Yeast, by Ms Kusum Yadav to Amity University Haryana, Gurugram Awarded on 27-07-2023, Supervisor -Prof Rajendra Prasad, Co -Supervisor Dr.Ravi Datta Sharma, |
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PhD Thesis: Small Peptides Prediction Using Machine Learning Methods, by Ms Ankita Tripathi to Amity University Haryana, Gurugram Awarded on 19-07-2023, Supervisor -Dr.Ravi Datta Sharma, Co -Supervisor Dr. Tapus Goswami |
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PhD Thesis: Insights into Mycobacterium tuberculosis dormancy adaptation in axenic culture and intracellular milieu from transcriptome analysis, by Ms Malobi Nandi to Amity University Haryana, Gurugram submitted on January, 2020, Awarded 14-08-2020,Supervisor -Dr.Ravi Datta Sharma, Co -Supervisor Prof. Jaya Tyagi, Shodhganga Link |
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PhD Thesis: Identification of molecular targets for the treatment of prostate cancer, by Ms. Julie Pratibha Singh to Amity University Haryana, Gurugram, Awarded 15-03-2021, Supervisor- Dr. Gargi Bagchi, Co-Supervisor- Prof. Rakesh Tyagi, Professor, Co-Supervisor- Dr. Ravi Datta Sharma, Shodhganga Link |
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M.Sc Biotechnology thesis:“Molecular docking of a non-nucleoside analogue into the binding pocket of reverse transcriptase enzyme”by Raghukul Chaudhary, Amity University Haryana, 2020 |
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B.Tech+M.Tech (Dual)Biotech thesis:“Statistical analysis of RNA-Seq data and development of a novel method to predict survival rate of cancer patients,Amity University Haryana, by Harsh Sharma, 2019 |
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M.S Bioinformatics thesis:“Next Generation Sequencing as a tool to study the role of differential expression and alternative splicing in Arabidopsis thaliana”, Bert Bogaerts,KU Leuven, Belgium 2015 |
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M.Phil Thesis: “High temperature unfolding of small chlorotoxin”,CCS University Meerut, Nitin Verma, 2009 |
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International Symposium on “Current trends in Computational biology and Data Science”, organized by Amity University Haryana, Gurugram, 4thNovember 2020 |
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2nd An international Symposium on Lipids on the forefront: A lot to Discover at Amity University Haryana,Gurugram 12-13 December, 2019 |
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DST sponsored a two-week national Training/FDP/ Workshop on Blockchain technology, 29th July to 9th August,2019 |
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Symposium on“World TB Day: Challenges to win MTR-TB” at Amity University Haryana,Gurugram, 27 March, 2019 |
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From Genes to Network: Recent trends in Cell-Signaling at Amity University Haryana, Gurugram, 14-15 December, 2018 |
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35th SMYTE-A small meeting on Yeast Transport and Energetics at Amity University Haryana, Gurugram 17-21 September, 2017 |
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“A brain storming day on Data Science and Predictive analytics” at Amity University Haryana, Gurugram, 9 June, 2017 |
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On topic “Alternative splicing based biomarker discovery using NGS technologies”at National Conference on Emerging Trends in Biotechnology and Food Engineering organised by Sharda University, Greater Noida, UP, 4th-5th April 2024 |
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“Alternative Splicing based Transcriptional BioMarkers Discovery using NGS- Technology”in a six-month certificate course on “Computer Assisted Drug Design” (CADD), jointly with Centre for Converging Technologies, University of Rajasthan under the Design and Innovation Centre (DIC) and Birla Institute of Scientific Research(BISR), Jaipur, Rajasthan, sponsored by Department of Education, Ministry of Human Resource Development, Government of India.10th February 2024 |
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“Prediction of numbers and concentration of Alternative splicing based transcriptional biomarkers using FASE software”in The 22nd International Conference on Bioinformatics (InCoB) organized by Translational Research Institute (TRI),Brisbane,Australia , 12th -15th November 2023 |
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On Topic “Prediction of numbers and concentration of Alternative splicing based transcriptional biomarkers using RNA-Seq Data”in International conference on recent trends in Biotechnology & applied Bioinformatics (ICRTBAB) 2023 organized by Department of Biotechnology (DBT) and Sharda University, Greater Noida, 27th -29th April 2023 |
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FDP –“Recent Advancements, Innovations, Future Trends in Emerging Technologies & Their Impact on Higher Education”, Talk title; “Artificial Intelligence in Healthcare,17th -21th July 2023 |
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On Topic of “Alternative splicing as a tool to find biomarkers” in COLLOQUIUM ON “Emerging Trends in Genome Editing”, organized by Amity University Uttar Pradesh. 7th January 2021 |
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FDP- Integrative Biology: From molecules to the ecosystem in health and medicine, 2-6th August 2021 |
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On Topic “Digital education: a worldwide prospective”in International E-Conference on Digital Education: Scope and Challenges in India, organised by Bharatiya Shikshan Mandal, Meerut Prant and Ch. Charan Singh University, Meerut, U.P., India, 27 & 28 June 2020 |
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On topic “Finding alternative Splicing events Using RNA- Seq” at Department of Life Science, Modi Institute of Management & Technology, Kota, Rajasthan, 17 December 2020 |
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On topic “Genomics for personalized medicine” at National Conference on Innovation and Entrepreneurship & Startup Summit (NCIESS 2020) organized by FITT, IIT Delhi and Startupindia & Atal, 22 January,2020 |
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Differential alternative Splicing using RNA-Seq data in Summer School organized by SCIS at JNU, 11th July, 2018 |
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On topic “Protein-protein interaction analysis using AP- Mass Spectrometry data from M.Tuberculosis”at International Lab Seminar 2014 organized by KULeuven CMPG Lab of Genetics and Genomics, and VIB Lab of System Biology by Prof Verstrepen at Sechry, Belgium, 2-6 June, 2014 |
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On topic “Protein-protein interaction analysis using AP- Mass Spectrometry data from M.Tuberculosis”at 4th SysteMTb Annual Meeting,Mallorca,Spain. 23-25 March, 2014 |
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On topic “Gene Expression Analysis”at Seminar, KU Leuven, Faculty of Bioscience Engineering, Department of Microbial and Molecular Systems, Kasteelpark,Arenberg 31, B-001,Heverlee,Belgium, 1st April, 2014 |
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